Lateral Flow Assay Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive MetalsâReplacing Colloidal Gold.
Nano Lett
; 24(20): 6069-6077, 2024 May 22.
Article
em En
| MEDLINE
| ID: mdl-38739779
ABSTRACT
Nanoparticles (NPs) can be conjugated with diverse biomolecules and employed in biosensing to detect target analytes in biological samples. This proven concept was primarily used during the COVID-19 pandemic with gold-NP-based lateral flow assays (LFAs). Considering the gold price and its worldwide depletion, here we show that novel plasmonic NPs based on inexpensive metals, titanium nitride (TiN) and copper covered with a gold shell (Cu@Au), perform comparable to or even better than gold nanoparticles. After conjugation, these novel nanoparticles provided high figures of merit for LFA testing, such as high signals and specificity and robust naked-eye signal recognition. Since the main cost of Au NPs in commercial testing kits is the colloidal synthesis, our development with the Cu@Au and the laser-ablation-fabricated TiN NPs is exciting, offering potentially inexpensive plasmonic nanomaterials for various bioapplications. Moreover, our machine learning study showed that biodetection with TiN is more accurate than that with Au.
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Base de dados:
MEDLINE
Assunto principal:
Titânio
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Cobre
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Nanopartículas Metálicas
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Ouro
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article