Severe drought exposure in utero associates to children's epigenetic age acceleration in a global climate change hot spot.
Nat Commun
; 15(1): 4140, 2024 May 16.
Article
em En
| MEDLINE
| ID: mdl-38755138
ABSTRACT
The goal of this study is to examine the association between in utero drought exposure and epigenetic age acceleration (EAA) in a global climate change hot spot. Calculations of EAA in adults using DNA methylation have been found to accurately predict chronic disease and longevity. However, fewer studies have examined EAA in children, and drought exposure in utero has not been investigated. Additionally, studies of EAA in low-income countries with diverse populations are rare. We assess EAA using epigenetic clocks and two DNAm-based pace-of-aging measurements from whole saliva samples in 104 drought-exposed children and 109 same-sex sibling controls in northern Kenya. We find a positive association between in utero drought exposure and EAA in two epigenetic clocks (Hannum's and GrimAge) and a negative association in the DNAm based telomere length (DNAmTL) clock. The combined impact of drought's multiple deleterious stressors may reduce overall life expectancy through accelerated epigenetic aging.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Mudança Climática
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Metilação de DNA
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Epigênese Genética
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Secas
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
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Pregnancy
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article