Plasma Neurofilament Light Relates to Divergent Default and Salience Network Connectivity in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia.
J Alzheimers Dis
; 99(3): 965-980, 2024.
Article
em En
| MEDLINE
| ID: mdl-38759005
ABSTRACT
Background:
Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) show differential vulnerability to large-scale brain functional networks. Plasma neurofilament light (NfL), a promising biomarker of neurodegeneration, has been linked in AD patients to glucose metabolism changes in AD-related regions. However, it is unknown whether plasma NfL would be similarly associated with disease-specific functional connectivity changes in AD and bvFTD.Objective:
Our study examined the associations between plasma NfL and functional connectivity of the default mode and salience networks in patients with AD and bvFTD.Methods:
Plasma NfL and neuroimaging data from patients with bvFTD (nâ=â16) and AD or mild cognitive impairment (nâ=â38; ADâ+âMCI) were analyzed. Seed-based functional connectivity maps of key regions within the default mode and salience networks were obtained and associated with plasma NfL in these patients.RESULTS:
We demonstrated divergent associations between NfL and functional connectivity in ADâ+âMCI and bvFTD patients. Specifically, ADâ+âMCI patients showed lower default mode network functional connectivity with higher plasma NfL, while bvFTD patients showed lower salience network functional connectivity with higher plasma NfL. Further, lower NfL-related default mode network connectivity in ADâ+âMCI patients was associated with lower Montreal Cognitive Assessment scores and higher Clinical Dementia Rating sum-of-boxes scores, although NfL-related salience network connectivity in bvFTD patients was not associated with Neuropsychiatric Inventory Questionnaire scores.CONCLUSIONS:
Our findings indicate that plasma NfL is differentially associated with brain functional connectivity changes in AD and bvFTD.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Biomarcadores
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Proteínas de Neurofilamentos
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Demência Frontotemporal
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Doença de Alzheimer
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article