Rigor and reproducibility in human brain organoid research: Where we are and where we need to go.
Stem Cell Reports
; 19(6): 796-816, 2024 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-38759644
ABSTRACT
Human brain organoid models have emerged as a promising tool for studying human brain development and function. These models preserve human genetics and recapitulate some aspects of human brain development, while facilitating manipulation in an in vitro setting. Despite their potential to transform biology and medicine, concerns persist about their fidelity. To fully harness their potential, it is imperative to establish reliable analytic methods, ensuring rigor and reproducibility. Here, we review current analytical platforms used to characterize human forebrain cortical organoids, highlight challenges, and propose recommendations for future studies to achieve greater precision and uniformity across laboratories.
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1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Organoides
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article