Cancer progression and tumor hypercoagulability: a platelet perspective.
J Thromb Thrombolysis
; 57(6): 959-972, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38760535
ABSTRACT
Venous thromboembolism, which is common in cancer patients and accompanies or even precedes malignant tumors, is known as cancer-related thrombosis and is an important cause of cancer- associated death. At present, the exact etiology of the elevated incidence of venous thrombosis in cancer patients remains elusive. Platelets play a crucial role in blood coagulation, which is intimately linked to the development of arterial thrombosis. Additionally, platelets contribute to tumor progression and facilitate immune evasion by tumors. Tumor cells can interact with the coagulation system through various mechanisms, such as producing hemostatic proteins, activating platelets, and directly adhering to normal cells. The relationship between platelets and malignant tumors is also significant. In this review article, we will explore these connections.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
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Progressão da Doença
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Trombofilia
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article