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Innovative Fusion of Probiotics and Mouth Fresheners: Investigating Unaltered Growth, Microscopic Analysis, and Mucoadhesive Strength.
Patel, Swayamprakash; Patel, Meet; Kaushik, Gaurav; Patel, Mruduka S; Desai, Jagruti; Patel, Mehul.
Afiliação
  • Patel S; Department of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa, India. Swayamprakashpatel.ph@charusat.ac.in.
  • Patel M; Department of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa, India.
  • Kaushik G; Research and Development (Clinical), Meteroic Biopharmaceuticals, Ahmedabad, India.
  • Patel MS; Research and Development (Clinical), Meteroic Biopharmaceuticals, Ahmedabad, India.
  • Desai J; Department of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa, India.
  • Patel M; Department of Pharmaceutics, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa, India.
Int J Pharm Compd ; 28(3): 249-259, 2024.
Article em En | MEDLINE | ID: mdl-38768505
ABSTRACT
Since ancient times, mouth fresheners in many different forms have been used throughout the world. Traditional knowledge describes the health benefits of mouth fresheners, and contemporary science is now investigating their benefits. Claims have been made that mouth fresheners not only improve digestion but also promote oral health. Similar, but in a more profound sense, probiotics offer astounding advantages in treating many disorders. In certain cases, probiotics also offer prophylactic effects. Numerous benefits for dental health are being studied for B. coagulans (MB-BCM9) and B. subtilis (MB-BSM12). In this current study, a probiotic and a mouth freshener were combined to ameliorate the impacts of both. The oral residence of probiotics was enhanced by employing mucoadhesive polymers. Numerous compositions were developed and evaluated for the unaltered growth of probiotics, along with other evaluations like microscopy, in vitro mucoadhesive strength, and stability studies. Xanthan gum and hydroxypropyl methylcellulose were used in the development of mucoadhesive probiotic powder by employing the lyophilization technique. More than five hours of residence time were observed in the in vitro study with goat oral mucosa. The enumeration study validated the label claims of MB-BCM9 and MB-BSM12. It also concluded that none of the components of the formulation had a detrimental effect on probiotics. In essence, the present work discloses the novel and stable formulation of a probiotic-based mouth freshener.
Assuntos
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Base de dados: MEDLINE Assunto principal: Polissacarídeos Bacterianos / Probióticos / Derivados da Hipromelose / Mucosa Bucal Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Polissacarídeos Bacterianos / Probióticos / Derivados da Hipromelose / Mucosa Bucal Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article