Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner.
Chem Res Toxicol
; 37(6): 1035-1043, 2024 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-38771972
ABSTRACT
Chlorobenzoquinones (CBQs) are a class of emerging water disinfection byproducts that pose significant risks to public health. In this study, we found that three CBQs (tetrachloro-1,4-benzoquinone, 2,5-dichloro-1,4-benzoquinone, and 2-chloro-1,4-benzoquinone) can significantly aggravate cell death caused by Ras-selective lethal small molecule 3 (RSL3). Further study showed that the cell death caused by CBQs, either alone or in combination with RSL3, was related to iron accumulation and GPX4 inactivation, suggesting the occurrence of ferroptosis. Furthermore, reactive oxygen species are found to play a potential key role in mediating the toxicity of CBQs in CBQs and RSL3-induced ferroptosis. These findings will be helpful in understanding the toxic mechanism of CBQs to mammalian cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzoquinonas
/
Espécies Reativas de Oxigênio
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Ferroptose
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article