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The effect of enriched versus depleted housing on eucalyptus smoke-induced cardiovascular dysfunction in mice.
Harmon, Molly E; Fiamingo, Michelle; Toler, Sydnie; Lee, Kaleb; Kim, Yongho; Martin, Brandi; Gilmour, Ian; Farraj, Aimen K; Hazari, Mehdi S.
Afiliação
  • Harmon ME; Curriculum in Toxicology and Environmental Medicine, University of NC - Chapel Hill, Chapel Hill, NC, USA.
  • Fiamingo M; Curriculum in Toxicology and Environmental Medicine, University of NC - Chapel Hill, Chapel Hill, NC, USA.
  • Toler S; Gillings School of Global Public Health, University of North Carolina - Chapel Hill, Chapel Hill, NC, USA.
  • Lee K; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
  • Kim Y; Public Health Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, NC, USA.
  • Martin B; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
  • Gilmour I; Public Health Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, NC, USA.
  • Farraj AK; Public Health Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, NC, USA.
  • Hazari MS; Public Health Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, NC, USA.
Inhal Toxicol ; : 1-12, 2024 May 22.
Article em En | MEDLINE | ID: mdl-38776456
ABSTRACT

Objectives:

Living conditions play a major role in health and well-being, particularly for the cardiovascular and pulmonary systems. Depleted housing contributes to impairment and development of disease, but how it impacts body resiliency during exposure to environmental stressors is unknown. This study examined the effect of depleted (DH) versus enriched housing (EH) on cardiopulmonary function and subsequent responses to wildfire smoke. Materials and

Methods:

Two cohorts of healthy female mice, one of them surgically implanted with radiotelemeters for the measurement of electrocardiogram, body temperature (Tco) and activity, were housed in either DH or EH for 7 weeks. Telemetered mice were exposed for 1 h to filtered air (FA) and then flaming eucalyptus wildfire smoke (WS) while untelemetered mice, which were used for ventilatory assessment and tissue collection, were exposed to either FA or WS. Animals were continuously monitored for 5-7 days after exposure.

Results:

EH prevented a decrease in Tco after radiotelemetry surgery. EH mice also had significantly higher activity levels and lower heart rate during and after FA and WS. Moreover, EH caused a decreased number of cardiac arrhythmias during WS. WS caused ventilatory depression in DH mice but not EH mice. Housing enrichment also upregulated the expression of cardioprotective genes in the heart.

Conclusions:

The results of this study indicate that housing conditions impact overall health and cardiopulmonary function. More importantly, depleted housing appears to worsen the response to air pollution. Thus, non-chemical factors should be considered when assessing the susceptibility of populations, especially when it comes to extreme environmental events.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article