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Exploring the role of Orexin-A neuropeptide in Parkinson's disease: A systematic review and meta-analysis.
Suresh, Vinay; Bardhan, Mainak; Ghosh, Shankhaneel; Chandani, Yash; Satapathy, Prakasini; Roy, Priyanka; Shamim, Muhammad Aaqib; Gandhi, Aravind P; Sandeep, Mokanpally; Rustagi, Sarvesh; Sah, Ranjit; Padhi, Bijaya K.
Afiliação
  • Suresh V; King George's Medical University, Lucknow 226003, India; Global Center for Evidence Synthesis, Chandigarh, 160036 India.
  • Bardhan M; Department of Neuro oncology,Miami Cancer Institute, Baptist Health South Florida,USA. Electronic address: mainak.bardhan@baptisthealth.net.
  • Ghosh S; Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan, Bhubaneswar, India.
  • Chandani Y; King George's Medical University, Lucknow 226003, India.
  • Satapathy P; Global Center for Evidence Synthesis, Chandigarh, 160036 India.
  • Roy P; Deputy Chief Inspector of Factories/ Deputy Director (Medical) and Certifying Surgeon, Directorate of Factories, Department of Labour, Government of West Bengal, India.
  • Shamim MA; Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur 342008, India.
  • Gandhi AP; Global Center for Evidence Synthesis, Chandigarh, 160036 India; Assistant Professor, Department of Community Medicine, ESIC Medical College & Hospital, Sanath Nagar, Hyderabad, India.
  • Sandeep M; Global Center for Evidence Synthesis, Chandigarh, 160036 India; School of Medical Sciences, University of Hyderabad, Telangana 500046, India.
  • Rustagi S; School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.
  • Sah R; Tribhuvan University Teaching Hospital, Kathmandu 46000, Nepal; Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra 411018, India; Department of Clinical Microbiology, DY Patil Medical College, Hospital and Research Centre,
  • Padhi BK; Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address: bkpadhi@gmail.com.
Clin Neurol Neurosurg ; 242: 108320, 2024 07.
Article em En | MEDLINE | ID: mdl-38781804
ABSTRACT

BACKGROUND:

Parkinson's disease (PD) is a progressive neurological condition that affects movement and coordination. Orexin-A (OXA) is an excitatory neuropeptide that is found throughout the central nervous system. There is growing interest in investigating the potential diagnostic and therapeutic utility of OXA in PD. To date, studies have reported a wide range of OXA concentrations in patients with PD. In this review, we discuss the current understanding of the dysregulation of OXA in PD and analyze its levels in the CSF.

METHODS:

We searched six databases (PubMed, Scopus, Web of Science, EMBASE, ProQuest, and EBSCOHost) and preprint servers using a predetermined search strategy through 4th March 4, 2023. The search keywords included "Parkinson's disease", "Orexin-A", "Hypocretin-1", "cerebrospinal fluid", and "CSF". Studies that reported OXA/Hypocretin-1 levels in the CSF of patients with PD were included. Two researchers independently reviewed the records and extracted data.

FINDINGS:

Eighteen studies involving 244 patients were analyzed. CSF Orexin-A concentrations were lower in patients with Parkinson's disease than in controls, with a mean difference of -59.21 (95 % CI -89.10 to -29.32). The mean OXA levels were 281.52 (95 % CI 226.65-336.40).

CONCLUSION:

Our analysis reveals lower concentrations of orexin-A in the cerebrospinal fluid of Parkinson's disease patients compared to controls, but within the normal range. These findings suggest a potential, but not significant, disruption in the orexinergic system associated with the disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Orexinas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Orexinas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article