IL-27 promotes pathogenic T cells in a mouse model of Sjögren's disease.
Clin Immunol
; 264: 110260, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38788885
ABSTRACT
Sjögren's disease (SjD) is a chronic autoimmune disease characterized by focal lymphocytic inflammation in lacrimal and salivary glands. We recently identified IL-27 as a requisite signal for the spontaneous SjD-like manifestations in nonobese diabetic (NOD) mice. Here, we define T cell-intrinsic effects of IL-27 in lacrimal gland disease in NOD mice. IL-27 receptor was required by both CD4 T effector (Te) cells and CD8 T cells to mediate focal inflammation. Intrinsic IL-27 signaling was associated with PD-1 and ICOS expressing T follicular helper (Tfh)-like CD4 Te cells within lacrimal glands, including subsets defined by CD73 or CD39 expression. CD8 T cells capable of IL-27 signaling also expressed PD-1 with subsets expressing ICOS and CD73 demonstrating a T follicular cytotoxic (Tfc)-like cell phenotype and others expressing a CD39hi exhausted-like phenotype. These findings suggest IL-27 is a key early signal driving a follicular-type response in lacrimal gland inflammation in NOD mice.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Sjogren
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Camundongos Endogâmicos NOD
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Linfócitos T CD8-Positivos
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Modelos Animais de Doenças
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Aparelho Lacrimal
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article