(Single-stranded DNA) gaps in understanding BRCAness.
Trends Genet
; 40(9): 757-771, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38789375
ABSTRACT
The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly distinct functions - homologous recombination, replication fork protection, and single-stranded (ss)DNA gap suppression - and their relative importance is under debate. In this review, we examine the origin and resolution of ssDNA gaps and discuss the recent advances in understanding the role of BRCA1/2 in gap suppression. There are ample data showing that gap accumulation in BRCA1/2-deficient cells is linked to genomic instability and chemosensitivity. However, it remains unclear whether there is a causative role and the function of BRCA1/2 in gap suppression cannot unambiguously be dissected from their other functions. We therefore conclude that the three functions of BRCA1 and 2 are closely intertwined and not mutually exclusive.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA de Cadeia Simples
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Proteína BRCA1
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Proteína BRCA2
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article