NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1.
Cell Mol Life Sci
; 81(1): 237, 2024 May 25.
Article
em En
| MEDLINE
| ID: mdl-38795132
ABSTRACT
Ovarian endometriosis is a common gynecological disease, and one of its most significant symptoms is infertility. In patients with endometriosis, defects in endometrial decidualization lead to impaired endometrial receptivity and embryo implantation, thus affecting early pregnancy and women's desire to have children. However, the mechanisms underlying the development of endometriosis and its associated defective decidualization are unclear. We find that NEK2 expression is increased in the ectopic and eutopic endometrium of patients with endometriosis. Meanwhile, NEK2 interacts with FOXO1 and phosphorylates FOXO1 at Ser184, inhibiting the stability of the FOXO1 protein. Importantly, NEK2-mediated phosphorylation of FOXO1 at Ser184 promotes cell proliferation, migration, invasion and impairs decidualization. Furthermore, INH1, an inhibitor of NEK2, inhibits the growth of ectopic lesions in mouse models of endometriosis and promotes endometrial decidualization in mouse models of artificially induced decidualization. Taken together, these findings indicate that NEK2 regulates the development of endometriosis and associated disorders of decidualization through the phosphorylation of FOXO1, providing a new therapeutic target for its treatment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proliferação de Células
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Endometriose
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Endométrio
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Quinases Relacionadas a NIMA
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Proteína Forkhead Box O1
Limite:
Adult
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Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article