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Different genetic profiles contribute to worse overall survival in patients with leptomeningeal metastases of non-small-cell lung cancer.
Tang, Xusheng; Hu, Xiaojuan; Yuan, Lin; Yang, Hainan; Luo, Yunfen; Liu, Da; Hu, Qingjun; Shan, Changguo; Lin, Tao; Cai, Linbo; Zhou, Zhaoming; Jin, Xin; Lei, Ming; Hong, Weiping.
Afiliação
  • Tang X; Department of Radiation Oncology, Shanghai GoBroad Cancer Hospital, Shanghai, China.
  • Hu X; Department of Oncology, Shanghai GoBroad Cancer Hospital, Shanghai, China.
  • Yuan L; Department of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Pudong New District, Shanghai, 200137, China.
  • Yang H; Department of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Pudong New District, Shanghai, 200137, China.
  • Luo Y; Department of Oncology, Shanghai GoBroad Cancer Hospital, Shanghai, China.
  • Liu D; Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangzhou, 510510, China.
  • Hu Q; Department of Oncology, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangzhou, 510510, China.
  • Shan C; Department of Oncology, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangzhou, 510510, China.
  • Lin T; Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangzhou, 510510, China.
  • Cai L; Department of Oncology, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangzhou, 510510, China.
  • Zhou Z; Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Jin X; Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangzhou, 510510, China. jinxin_1217@126.com.
  • Lei M; Department of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Pudong New District, Shanghai, 200137, China. leiming6891@163.com.
  • Hong W; Department of Oncology, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangzhou, 510510, China. Hongweiping999@126.com.
Clin Transl Oncol ; 2024 May 25.
Article em En | MEDLINE | ID: mdl-38795257
ABSTRACT

BACKGROUND:

To assess the genetic characteristics of central nervous system (CNS) metastases from non-small-cell lung cancer (NSCLC), we gathered the genetic profiles of brain metastases (BM) and leptomeningeal metastases (LM). Our objective was to identify genetic factors contributing to poorer overall survival (OS) in NSCLC patients with LM.

METHODS:

This study included 25 consecutive patients with BM and 52 patients with LM from Guangdong Sanjiu Brain Hospital. All participants underwent 168-target panel sequencing.

RESULTS:

Among the 25 patients with BM, TP53 was the most frequently mutated gene (44%), followed by driver genes such as EGFR and BRAF (40% and 20%, respectively). In patients with BM, EGFR_amp and CDK4 were also frequently mutated, with rates of 20% and 16%, respectively. The genetic landscape of patients with LM differed, with the top mutated genes being EGFR, TP53, EGFR_amp, CDKN2A, CCNE1, CDK4, PMS2, and PIK3CA, with mutation rates of 77%, 69%, 31%, 29%, 13%, 13%, 13%, and 12%, respectively. In our study, patients with LM exhibited significantly worse OS compared to those with BM (p = 0.029). The mutation rates of TP53, EGFR_amp, and CDKN2A varied between patients with LM and those with BM, at 69.23% vs. 44%, 30.77% vs. 20%, and 28.85% vs. 12%, respectively. Further exploration revealed that patients with BM with TP53 mutations had a shorter OS than patients without TP53 mutations (p = 0.014). Similarly, patients with LM and TP53 mutations presented with worse OS than those without TP53 mutations (p = 0.0067). LM patients with CDKN2A deletions had worse OS than those without CDKN2A deletions (p = 0.037). Additionally, patients with EGFR_amp had a shorter OS than those without EGFR_amp (p = 0.044).

CONCLUSIONS:

Patients with LM exhibited significantly worse OS than those with BM. Gene signatures, such as TP53, EGFR_amp, and CDKN2A, may account for shorter outcomes in patients with LM.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article