The myriad roles of RNA structure in the flavivirus life cycle.
RNA Biol
; 21(1): 14-30, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38797925
ABSTRACT
As positive-sense RNA viruses, the genomes of flaviviruses serve as the template for all stages of the viral life cycle, including translation, replication, and infectious particle production. Yet, they encode just 10 proteins, suggesting that the structure and dynamics of the viral RNA itself helps shepherd the viral genome through these stages. Herein, we highlight advances in our understanding of flavivirus RNA structural elements through the lens of their impact on the viral life cycle. We highlight how RNA structures impact translation, the switch from translation to replication, negative- and positive-strand RNA synthesis, and virion assembly. Consequently, we describe three major themes regarding the roles of RNA structure in flavivirus infections 1) providing a layer of specificity; 2) increasing the functional capacity; and 3) providing a mechanism to support genome compaction. While the interactions described herein are specific to flaviviruses, these themes appear to extend more broadly across RNA viruses.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
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RNA Viral
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Genoma Viral
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Flavivirus
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Conformação de Ácido Nucleico
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article