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Photobiomodulation improves acute restraint stress-induced visceral hyperalgesia in rats.
Ishibashi, Naoya; Nanjo, Takuya; Tao, Shinichi.
Afiliação
  • Ishibashi N; Bio-medical Engineering Group, Drug Discovery Laboratory, Teijin Institute for Bio-medical Research, Teijin Pharma Ltd., 4-3-2, Asahigaoka, Hino-shi, Tokyo, 191-8512, Japan. n.ishibashi@teijin.co.jp.
  • Nanjo T; Bio-medical Engineering Group, Drug Discovery Laboratory, Teijin Institute for Bio-medical Research, Teijin Pharma Ltd., 4-3-2, Asahigaoka, Hino-shi, Tokyo, 191-8512, Japan.
  • Tao S; Bio-medical Engineering Group, Drug Discovery Laboratory, Teijin Institute for Bio-medical Research, Teijin Pharma Ltd., 4-3-2, Asahigaoka, Hino-shi, Tokyo, 191-8512, Japan.
Lasers Med Sci ; 39(1): 143, 2024 May 28.
Article em En | MEDLINE | ID: mdl-38806837
ABSTRACT
The purpose of this study is to explore the potential application of photobiomodulation to irritable bowel syndrome. We established the following experimental groups the Non-Stress + Sham group, which consisted of rats that were not restrained and were only subjected to sham irradiation; the Stress + Sham group, which underwent 1 hour of restraint stress followed by sham irradiation; and the Stress + Laser group, which was subjected to restraint stress and percutaneous laser irradiation bilaterally on the L6 dorsal root ganglia for 5 minutes each. The experiment was conducted twice, with three and two laser conditions examined. Following laser irradiation, a barostat catheter was inserted into the rat's colon. After a 30-minute acclimatization period, the catheter was inflated to a pressure of 60 mmHg, and the number of abdominal muscle contractions was measured over a 5-minute period. The results showed that photobiomodulation significantly suppressed the number of abdominal muscle contractions at average powers of 460, 70, and 18 mW. However, no significant suppression was observed at average powers of 1 W and 3.5 mW. This study suggests that photobiomodulation can alleviate visceral hyperalgesia induced by restraint stress, indicating its potential applicability to irritable bowel syndrome.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Restrição Física / Ratos Sprague-Dawley / Terapia com Luz de Baixa Intensidade / Síndrome do Intestino Irritável / Hiperalgesia Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Restrição Física / Ratos Sprague-Dawley / Terapia com Luz de Baixa Intensidade / Síndrome do Intestino Irritável / Hiperalgesia Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article