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Immobilising an acid-cleavable dimeric phthalocyanine on gold nanobipyramids for intracellular pH detection and photodynamic elimination of cancer cells.
Cao, Yue; Wong, Roy C H; Xue, Evelyn Y; Zhang, Han; Wang, Jie; Ding, Yan; Zhang, Lei; Chen, Feng; Wang, Jianfang; Ng, Dennis K P.
Afiliação
  • Cao Y; Department of Forensic Medicine, Nanjing Medical University, Nanjing 211166, China.
  • Wong RCH; Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. dkpn@cuhk.edu.hk.
  • Xue EY; Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. dkpn@cuhk.edu.hk.
  • Zhang H; Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. dkpn@cuhk.edu.hk.
  • Wang J; Department of Physics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
  • Ding Y; Department of Forensic Medicine, Nanjing Medical University, Nanjing 211166, China.
  • Zhang L; Department of Forensic Medicine, Nanjing Medical University, Nanjing 211166, China.
  • Chen F; State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
  • Wang J; Department of Forensic Medicine, Nanjing Medical University, Nanjing 211166, China.
  • Ng DKP; Department of Physics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Analyst ; 149(12): 3288-3292, 2024 Jun 10.
Article em En | MEDLINE | ID: mdl-38808583
ABSTRACT
An acetal-linked dimeric phthalocyanine has been synthesised and immobilised on the surface of gold nanobipyramids. The resulting nanocomposite serves as a highly sensitive probe for intracellular pH through its acid-responsive fluorescence and surface-enhanced Raman scattering signals. The phthalocyanine units released in the acidic intracellular environment can also effectively eliminate the cancer cells upon light irradiation, rendering this simple fabricated nanosystem a bimodal and bifunctional theranostic agent.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Isoindóis / Ouro / Indóis Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Isoindóis / Ouro / Indóis Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article