National practice patterns in the use of endoscopic ultrasound biopsy for resectable Pancreatic Neuroendocrine Tumors: Insights into the role of DOTATATE PET/CT in diagnosis.

Casey, Megan; Brown, Audrey; Romero-Hernandez, Fernanda; Wang, Jaeyun Jane; Ganjouei, Amir Ashraf; Tozzi, Francesca; Rashidian, Nikdokht; Kirkwood, Kimberly; Corvera, Carlos; Nakakura, Eric; Alseidi, Adnan; Adam, Mohamed

Casey, Megan; Brown, Audrey; Romero-Hernandez, Fernanda; Wang, Jaeyun Jane; Ganjouei, Amir Ashraf; Tozzi, Francesca; Rashidian, Nikdokht; Kirkwood, Kimberly; Corvera, Carlos; Nakakura, Eric; Alseidi, Adnan; Adam, Mohamed.

Afiliação

Casey M; School of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.
Brown A; Department of Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA.
Romero-Hernandez F; Department of Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA.
Wang JJ; Department of Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA.
Ganjouei AA; Department of Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA.
Tozzi F; Department of General, HPB Surgery and Liver Transplantation, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Rashidian N; Department of General, HPB Surgery and Liver Transplantation, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Kirkwood K; Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Corvera C; Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Nakakura E; Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Alseidi A; Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Adam M; Division of Surgical Oncology, University of California, San Francisco, San Francisco, CA, 94143, USA. Electronic address: mohamed.adam@ucsf.edu.

Am J Surg ; : 115779, 2024 May 23.

Article em En | MEDLINE | ID: mdl-38811243

ABSTRACT

ABSTRACT

INTRODUCTION:

Pancreatic neuroendocrine tumors (PNETs) are typically diagnosed using endoscopic ultrasound-guided (EUS) biopsy, which can be associated with complications. Since 2016, DOTATATE PET/CT has emerged as an effective tool to localize and stage PNETs.

METHODS:

Patients with PNETs who underwent R0 resections were identified from the 2004-2019 National Cancer Database PUF. Joinpoint regression and multivariable logistic regression were used to analyze trends in the use of biopsy.

RESULTS:

Of 16,746 R0 resected PNET patients, 44 â% underwent diagnostic biopsy. Joinpoint regression showed a significant increase in the use of biopsy from 2004 to 2019 (APC 1.80, p â< â0.001). A higher percentage of patients diagnosed after DOTATATE approval underwent biopsy compared to those diagnosed before (48 â% vs. 42 â%, p â< â0.001). Adjusted analysis showed diagnosis after 2016 was associated with increased odds of biopsy (OR â= â1.67, p â< â0.001).

CONCLUSIONS:

Despite technologic advancement with DOTATATE PET/CT, there has been a significant increase in the proportion of resectable PNETs undergoing preoperative biopsy.

Palavras-chave

DOTATATE PET/CT; Pancreatic neuroendocrine tumor; Ultrasound-guided biopsy

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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