Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance.
Cell Rep
; 43(6): 114276, 2024 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-38814781
ABSTRACT
How the coordination of neuronal spiking and brain rhythms between hippocampal subregions supports memory function remains elusive. We studied the interregional coordination of CA3 neuronal spiking with CA1 theta oscillations by recording electrophysiological signals along the proximodistal axis of the hippocampus in rats that were performing a high-memory-demand recognition memory task adapted from humans. We found that CA3 population spiking occurs preferentially at the peak of distal CA1 theta oscillations when memory was tested but only when previously encountered stimuli were presented. In addition, decoding analyses revealed that only population cell firing of proximal CA3 together with that of distal CA1 can predict performance at test in the present non-spatial task. Overall, our work demonstrates an important role for the synchronization of CA3 neuronal activity with CA1 theta oscillations during memory testing.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ritmo Teta
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Região CA1 Hipocampal
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Região CA3 Hipocampal
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Memória
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Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article