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SenNet recommendations for detecting senescent cells in different tissues.
Suryadevara, Vidyani; Hudgins, Adam D; Rajesh, Adarsh; Pappalardo, Alberto; Karpova, Alla; Dey, Amit K; Hertzel, Ann; Agudelo, Anthony; Rocha, Azucena; Soygur, Bikem; Schilling, Birgit; Carver, Chase M; Aguayo-Mazzucato, Cristina; Baker, Darren J; Bernlohr, David A; Jurk, Diana; Mangarova, Dilyana B; Quardokus, Ellen M; Enninga, Elizabeth Ann L; Schmidt, Elizabeth L; Chen, Feng; Duncan, Francesca E; Cambuli, Francesco; Kaur, Gagandeep; Kuchel, George A; Lee, Gung; Daldrup-Link, Heike E; Martini, Helene; Phatnani, Hemali; Al-Naggar, Iman M; Rahman, Irfan; Nie, Jia; Passos, João F; Silverstein, Jonathan C; Campisi, Judith; Wang, Julia; Iwasaki, Kanako; Barbosa, Karina; Metis, Kay; Nernekli, Kerem; Niedernhofer, Laura J; Ding, Li; Wang, Lichao; Adams, Lisa C; Ruiyang, Liu; Doolittle, Madison L; Teneche, Marcos G; Schafer, Marissa J; Xu, Ming; Hajipour, Mohammadjavad.
Afiliação
  • Suryadevara V; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
  • Hudgins AD; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
  • Rajesh A; Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA.
  • Pappalardo A; Department of Dermatology, Columbia University, New York, NY, USA.
  • Karpova A; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Dey AK; National Institute on Aging, NIH, Baltimore, MD, USA.
  • Hertzel A; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Agudelo A; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
  • Rocha A; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
  • Soygur B; Center on the Biology of Aging, Brown University, Providence, RI, USA.
  • Schilling B; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
  • Carver CM; Center on the Biology of Aging, Brown University, Providence, RI, USA.
  • Aguayo-Mazzucato C; The Buck Institute for Research on Aging, Novato, CA, USA.
  • Baker DJ; The Buck Institute for Research on Aging, Novato, CA, USA.
  • Bernlohr DA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • Jurk D; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.
  • Mangarova DB; Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA.
  • Quardokus EM; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.
  • Enninga EAL; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
  • Schmidt EL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Chen F; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
  • Duncan FE; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • Cambuli F; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.
  • Kaur G; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Kuchel GA; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
  • Lee G; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.
  • Daldrup-Link HE; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
  • Martini H; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Phatnani H; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
  • Al-Naggar IM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Rahman I; The Buck Institute for Research on Aging, Novato, CA, USA.
  • Nie J; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Passos JF; New York Genome Center, New York, NY, USA.
  • Silverstein JC; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
  • Campisi J; UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
  • Wang J; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA.
  • Iwasaki K; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • Barbosa K; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.
  • Metis K; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
  • Nernekli K; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • Niedernhofer LJ; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.
  • Ding L; New York Genome Center, New York, NY, USA.
  • Wang L; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
  • Adams LC; UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
  • Ruiyang L; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
  • Doolittle ML; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Teneche MG; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • Schafer MJ; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.
  • Xu M; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Hajipour M; The Buck Institute for Research on Aging, Novato, CA, USA.
Nat Rev Mol Cell Biol ; 2024 Jun 03.
Article em En | MEDLINE | ID: mdl-38831121
ABSTRACT
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest. By contrast, in tissues, these cells are relatively rare and difficult to characterize, and it is now established that fully differentiated, postmitotic cells can also acquire a senescence phenotype. The SenNet Biomarkers Working Group was formed to provide recommendations for the use of cellular senescence markers to identify and characterize senescent cells in tissues. Here, we provide recommendations for detecting senescent cells in different tissues based on a comprehensive analysis of existing literature reporting senescence markers in 14 tissues in mice and humans. We discuss some of the recent advances in detecting and characterizing cellular senescence, including molecular senescence signatures and morphological features, and the use of circulating markers. We aim for this work to be a valuable resource for both seasoned investigators in senescence-related studies and newcomers to the field.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article