Correlation Between Depth of Dexmedetomidine Anesthesia and Cognitive Function in Patients Undergoing Laparoscopic Myomectomy under General Anesthesia.

ABSTRACT

Purpose: To analyze the correlation between the depth of dexmedetomidine anesthesia and cognitive function in patients undergoing laparoscopic myomectomy under general anesthesia. Methods: According to the inclusion and exclusion criteria, 180 patients who underwent laparoscopic myomectomy under general anesthesia using dexmedetomidine in the gynecology department of our hospital from February 2021 to February 2022 were retrospectively analyzed as study subjects. All patients were monitored by BIS intraoperatively, and the patients were divided into 3 groups according to BIS group I (n=48), group II (n=105), and group III (n=27). The MMSE scores of patients in the three groups were measured 1 d before anesthesia, 1 d, 3 d, and 5 d after surgery, respectively, and the TMT completion times of patients in the three groups were measured 1 d before anesthesia and 1 d after surgery, and the mean postoperative anesthesia wakefulness time of patients in the three groups and the incidence of cognitive dysfunction in the three groups were recorded. Finally, the BIS of patients in the three groups was compared with the MMSE scores of patients at 5 d after surgery, the TMT completion time at 1 d after surgery, the anesthesia wakefulness time, and the rate of cognitive dysfunction was correlated. Results: There was a significant difference in MMSE scores between the three groups at 1 d, 3 d, and 5 d postoperatively (P < .05); meanwhile, the MMSE scores were significantly higher in group I compared with groups II and III at 1 d, 3 d, and 5 d postoperatively (all P < .05). At 1 d postoperatively for the three groups TMT completion time compared with preoperative time, the difference between the groups was significant (P < .05); meanwhile, compared with 1 d postoperatively in groups II and III, TMT completion time was significantly lower in group I (P < .05). The rate of cognitive dysfunction and the mean postoperative anesthesia awake time of patients in group I were significantly reduced compared with groups II and III (P < .05). BIS was negatively correlated with the MMSE score at 5 d postoperatively, positively correlated with the TMT completion time at 1 d postoperatively, and positively correlated with the anesthesia awake time, and had no significant correlation with the rate of cognitive dysfunction in the three groups. Conclusion: The postoperative cognitive function of patients is closely related to the depth of anesthesia and is negatively correlated with the depth of anaesthesia, i.e. the deeper the depth of anaesthesia, the more pronounced the impairment of the cognitive function of the patient, and the more difficult it is to recover.