A mathematical framework for understanding the spontaneous emergence of complexity applicable to growing multicellular systems.
PLoS Comput Biol
; 20(6): e1011882, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38838038
ABSTRACT
In embryonic development and organogenesis, cells sharing identical genetic codes acquire diverse gene expression states in a highly reproducible spatial distribution, crucial for multicellular formation and quantifiable through positional information. To understand the spontaneous growth of complexity, we constructed a one-dimensional division-decision model, simulating the growth of cells with identical genetic networks from a single cell. Our findings highlight the pivotal role of cell division in providing positional cues, escorting the system toward states rich in information. Moreover, we pinpointed lateral inhibition as a critical mechanism translating spatial contacts into gene expression. Our model demonstrates that the spatial arrangement resulting from cell division, combined with cell lineages, imparts positional information, specifying multiple cell states with increased complexity-illustrated through examples in C.elegans. This study constitutes a foundational step in comprehending developmental intricacies, paving the way for future quantitative formulations to construct synthetic multicellular patterns.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Redes Reguladoras de Genes
/
Modelos Biológicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article