Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan.

Sada, Haruki; Hinoi, Takao; Niitsu, Hiroaki; Ohdan, Hideki; Yamamoto, Seiichiro; Endo, Shungo; Hida, Koya; Kinugasa, Yusuke; Enomoto, Toshiyuki; Maruyama, Satoshi; Konishi, Fumio; Watanabe, Masahiko

Sada, Haruki; Hinoi, Takao; Niitsu, Hiroaki; Ohdan, Hideki; Yamamoto, Seiichiro; Endo, Shungo; Hida, Koya; Kinugasa, Yusuke; Enomoto, Toshiyuki; Maruyama, Satoshi; Konishi, Fumio; Watanabe, Masahiko.

Afiliação

Sada H; Department of Surgery, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure, Hiroshima, 737-0023, Japan.
Hinoi T; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Niitsu H; Department of Clinical and Molecular Genetics, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. thinoi@hiroshima-u.ac.jp.
Ohdan H; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. thinoi@hiroshima-u.ac.jp.
Yamamoto S; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-Ku, Nagoya, Aichi, 464-8681, Japan.
Endo S; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Hida K; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Kinugasa Y; Department of Gastroenterological Surgery, Tokai University School of Medicine, 43 Shimokasuya, Isehara, Kanagawa, 259-1103, Japan.
Enomoto T; Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizu-Wakamatsu City, Fukushima, 969-3492, Japan.
Maruyama S; Department of Surgery, Kyoto University Hospital, Kyoto, Japan.
Konishi F; Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Watanabe M; Department of Surgery, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Meguro-Ku, Tokyo, Japan.

Surg Today ; 2024 Jun 05.

Article em En | MEDLINE | ID: mdl-38839654

ABSTRACT

ABSTRACT

PURPOSE:

This study investigated the impact of sidedness of colorectal cancer (CRC) in elderly patients on the prognosis.

METHODS:

In a sub-analysis of a multicenter case-control study of CRC patients who underwent surgery at ≥ 80 years old conducted in Japan between 2003 and 2007, both short- and long-term outcomes were compared between right-sided colon cancers (RCCs) and left-sided colorectal cancers (LCCs). RCCs were defined as those located from the cecum to the transverse colon.

RESULTS:

Among the 1680 patients who underwent curative surgery, 812 and 868 had RCCs and LCCs, respectively. RCCs were more frequent than LCCs in those who were female, had renal comorbidities, and had a history of abdominal surgery. Regarding tumor characteristics, RCCs were larger, invaded more deeply, and were diagnosed as either mucinous or signet ring-cell carcinoma more frequently than LCCs. Regarding the prognosis, patients with RCCs had a significantly longer cancer-specific survival (CS-S) and cancer-specific relapse-free survival (CS-RFS) than those with LCCs. Furthermore, sidedness was determined to be an independent prognostic factor for CS-S and CS-RFS.