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Lineage specification in glioblastoma is regulated by METTL7B.
Constantinou, Myrianni; Nicholson, James; Zhang, Xinyu; Maniati, Eleni; Lucchini, Sara; Rosser, Gabriel; Vinel, Claire; Wang, Jun; Lim, Yau Mun; Brandner, Sebastian; Nelander, Sven; Badodi, Sara; Marino, Silvia.
Afiliação
  • Constantinou M; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
  • Nicholson J; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
  • Zhang X; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
  • Maniati E; Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6AS, UK.
  • Lucchini S; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
  • Rosser G; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
  • Vinel C; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
  • Wang J; Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6AS, UK.
  • Lim YM; Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, and Department of Neurodegenerative Disease, Queen Square, Institute of Neurology, University College London, Queen Square, London, UK.
  • Brandner S; Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, and Department of Neurodegenerative Disease, Queen Square, Institute of Neurology, University College London, Queen Square, London, UK.
  • Nelander S; Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Badodi S; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
  • Marino S; Brain Tumour Research Centre, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK. Electronic address: s.marino@qmul.ac.uk.
Cell Rep ; 43(6): 114309, 2024 Jun 25.
Article em En | MEDLINE | ID: mdl-38848215
ABSTRACT
Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineage specification in glioblastoma, with an impact on both tumor size and invasiveness. Single-cell transcriptomic analysis of these tumors and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B reveal a regulatory role for the gene in the neural stem cell-to-astrocyte differentiation trajectory. Mechanistically, METTL7B downregulates the expression of key neuronal differentiation players, including SALL2, via post-translational modifications of histone marks.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Glioblastoma / Linhagem da Célula / Metiltransferases Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Glioblastoma / Linhagem da Célula / Metiltransferases Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article