Visible-Light-Induced Hydrodifluoromethylation of Unactivated Alkenes with Difluoroacetic Anhydride.
J Org Chem
; 89(12): 8828-8835, 2024 Jun 21.
Article
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| MEDLINE
| ID: mdl-38848324
ABSTRACT
We herein described a practical and efficient protocol for hydrodifluoromethylation of unactivated alkenes using readily available difluoroacetic anhydride as a difluoromethyl source by merging photocatalysis and N-hydroxyphthalimide activation. This method features a wide substrate scope and excellent compatibility with various functional groups, as demonstrated by more than 50 examples, including bioactive molecules and pharmaceutical derivatives. Mechanism investigation indicated that N-hydroxyphthalimide may also serve as the hydrogen atom donor.
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MEDLINE
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En
Ano de publicação:
2024
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Article