The lncRNA Gm8097 is associated with hypospermatogenesis.

Lei, Bin; Ye, Luwei; Qiu, Zhuolin; Zhang, Shoubo.

Afiliação

Lei B; Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Ye L; Department of Critical Care Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Qiu Z; Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhang S; Center for Reproductive Medicine, Guangdong Armed Police Hospital, Guangzhou Medical University, Guangzhou, China.

Clin Exp Reprod Med ; 2024 Jun 10.

Article em En | MEDLINE | ID: mdl-38853128

ABSTRACT

Objective:

To investigate whether long non-coding RNA (lncRNA) Gm8097 (LncGm8097) is associated with male infertility.

The expression and bilogical role of LncGm8097 were investigated.

LncGm8097 expression was down-regulated in the testis tissues with moderate and severe hypospermatogenesis compared with those with normal spermatogenesis and mild hypospermatogenesis (p<0.05). LncGm8097 down-regulation significantly promoted apoptosis and inhibited proliferation in GC1 and GC2 cells. In addition, LncGm8097 was significantly down-regulated in mouse model of hypospermatogenesis and correlated with cell apoptosis and proliferation. LncGm8097 was located immediately upstream of PRPS2, and correlated with Bcl-2/P53/caspase 6/caspase 9 signal pathway.