Three new antinociceptive diterpenoids from the fruits of Rhododendron molle.
J Asian Nat Prod Res
; 26(9): 1024-1032, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38853517
ABSTRACT
Investigation of the fruits of Rhododendron molle G. Don led to the isolation of three new grayanane-type diterpenoids, rhodomolleins LIV-LVI (1-3). The structures and absolute configurations of new compounds were fully elucidated by spectroscopic analysis and single-crystal X-ray diffraction, including HRESIMS, 1 D and 2 D NMR data. Compounds 1-3 were evaluated for analgesic activities utilizing an acetic acid-induced writhing test in mice. Compound 1 showed a significant antinociceptive effect with writhe inhibition rates of 72.9% and 100% at doses of 6 mg/kg and 20 mg/kg in mice, respectively. The binding mode of 1 to N-ethylmaleimide-sensitive factor (NSF, PDB 6IP2) was explored by molecular docking, indicating the presence of hydrogen bond interactions which account for its analgesic activity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rhododendron
/
Diterpenos
/
Frutas
/
Analgésicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article