Structural analysis of neomycin B and kanamycin A binding Aminoglycosides Modifying Enzymes (AME) and bacterial ribosomal RNA.
Mol Inform
; 43(7): e202300339, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38853661
ABSTRACT
Aminoglycosides are crucial antibiotics facing challenges from bacterial resistance. This study addresses the importance of aminoglycoside modifying enzymes in the context of escalating resistance. Drawing upon over two decades of structural data in the Protein Data Bank, we focused on two key antibiotics, neomycin B and kanamycin A, to explore how the aminoglycoside structure is exploited by this family of enzymes. A systematic comparison across diverse enzymes and the RNA A-site target identified common characteristics in the recognition mode, while assessing the adaptability of neomycin B and kanamycin A in various environments.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Bacteriano
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RNA Ribossômico
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Framicetina
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Canamicina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article