Presynaptic regulators in memory formation.
Learn Mem
; 31(5)2024 May.
Article
em En
| MEDLINE
| ID: mdl-38862173
ABSTRACT
The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small GTPase Rab3, enriched at synaptic vesicles, and the cell adhesion protein Neurexin-1, in the formation of distinct memory phases within the Drosophila mushroom body Kenyon cells. Our findings suggest that both proteins play crucial roles in memory-supporting processes within the presynaptic terminal, operating within distinct plasticity modules. These modules likely encompass remodeling and maturation of existing active zones (AZs), as well as the formation of new AZs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terminações Pré-Sinápticas
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Proteínas rab3 de Ligação ao GTP
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Corpos Pedunculados
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Proteínas de Drosophila
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Memória
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article