Investigation of hemispheric asymmetry in Alzheimer's disease patients during resting state revealed BY fNIRS.
Sci Rep
; 14(1): 13454, 2024 06 11.
Article
em En
| MEDLINE
| ID: mdl-38862632
ABSTRACT
Alzheimer's disease (AD) is characterized by the gradual deterioration of brain structures and changes in hemispheric asymmetry. Meanwhile, healthy aging is associated with a decrease in functional hemispheric asymmetry. In this study, functional connectivity analysis was used to compare the functional hemispheric asymmetry in eyes-open resting-state fNIRS data of 16 healthy elderly controls (mean age 60.4 years, MMSE (Mini-Mental State Examination) 27.3 ± 2.52) and 14 Alzheimer's patients (mean age 73.8 years, MMSE 22 ± 4.32). Increased interhemispheric functional connectivity was found in the premotor cortex, supplementary motor cortex, primary motor cortex, inferior parietal cortex, primary somatosensory cortex, and supramarginal gyrus in the control group compared to the AD group. The study revealed that the control group had stronger interhemispheric connectivity, leading to a more significant decrease in hemispheric asymmetry than the AD group. The results show that there is a difference in interhemispheric functional connections at rest between the Alzheimer's group and the control group, suggesting that functional hemispheric asymmetry continues in Alzheimer's patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Descanso
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Espectroscopia de Luz Próxima ao Infravermelho
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Doença de Alzheimer
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article