Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4<sup>+</sup> Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder.

Sun, Zuoli; Zhang, Bowen; Zhou, Jingjing; Luo, Yanting; Zhu, Xuequan; Wang, Yaping; He, Yi; Zheng, Peng; Zhang, Ling; Yang, Jian; Wang, Gang

Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4⁺ Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder.

Sun, Zuoli; Zhang, Bowen; Zhou, Jingjing; Luo, Yanting; Zhu, Xuequan; Wang, Yaping; He, Yi; Zheng, Peng; Zhang, Ling; Yang, Jian; Wang, Gang.

Afiliação

Sun Z; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Zhang B; College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Zhou J; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Luo Y; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Zhu X; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Wang Y; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
He Y; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Zheng P; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Zhang L; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yang J; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Wang G; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.

Adv Sci (Weinh) ; 11(30): e2308393, 2024 Aug.

Article em En | MEDLINE | ID: mdl-38867657

Assuntos

Antidepressivos; Linfócitos T CD4-Positivos; Transtorno Depressivo Maior; Análise de Célula Única; Humanos; Transtorno Depressivo Maior/genética; Transtorno Depressivo Maior/tratamento farmacológico; Transtorno Depressivo Maior/imunologia; Masculino; Antidepressivos/uso terapêutico; Antidepressivos/farmacologia; Feminino; Adulto; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/efeitos dos fármacos; Pessoa de Meia-Idade; Análise de Célula Única/métodos; Subpopulações de Linfócitos T/imunologia; Subpopulações de Linfócitos T/efeitos dos fármacos; Subpopulações de Linfócitos T/metabolismo; Diferenciação Celular/efeitos dos fármacos; Diferenciação Celular/genética; RNA-Seq/métodos; Análise de Sequência de RNA/métodos; Análise da Expressão Gênica de Célula Única

Palavras-chave

ATAC sequencing; CD4+ naive T cells; major depressive disorder; singlecell RNA sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Transtorno Depressivo Maior / Análise de Célula Única / Antidepressivos Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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