Associations of cholecystectomy with the risk of gastroesophageal reflux disease: a mendelian randomization study.
Int J Surg
; 2024 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-38869973
ABSTRACT
BACKGROUND:
Cholecystectomy is the standard surgery for patients with gallbladder disease, but the impact of cholecystectomy on gastroesophageal reflux disease (GERD) is not clear.METHODS:
We obtained genetic variants associated with cholecystectomy at a genome-wide significant level (P value<5 × 10-8) as instrumental variables (IVs) and performed Mendelian randomization (MR) to explore the relationship with GERD.RESULTS:
The Inverse Variance Weighted analysis (IVW) showed that the risk of GERD in patients after cholecystectomy increased (OR=2.19; 95% CI 1.18 - 4.09). At the same time, the analysis results of weighted median (OR=2.30; 95% CI 1.51 - 3.48) and weighted mode (OR=2.21; 95% CI 1.42 - 3.45) were also consistent with the direction of the IVW analysis and were statistically significant (P<0.05).CONCLUSIONS:
This study shows that patients who have undergone cholecystectomy are a susceptible population of GERD.
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Base de dados:
MEDLINE
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En
Ano de publicação:
2024
Tipo de documento:
Article