Associations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study.
J Alzheimers Dis
; 100(2): 487-494, 2024.
Article
em En
| MEDLINE
| ID: mdl-38875034
ABSTRACT
Background:
Associations of plasma total tau levels with future risk of AD have been described.Objective:
To examine the extent to which plasma tau reflects underlying AD brain pathology in cognitively healthy individuals.Methods:
We examined cross-sectional associations of plasma total tau with 11C-Pittsburgh Compound-B (PiB)-PET and 18F-Flortaucipir (FTP)-PET in middle-aged participants at the community-based Framingham Heart Study.Results:
Our final sample included 425 participants (mean age 57.6± 9.9, 50% F). Plasma total tau levels were positively associated with amyloid-ß deposition in the precuneus region (ß±SE, 0.11±0.05; pâ=â0.025). A positive association between plasma total tau and tau PET in the rhinal cortex was suggested in participants with higher amyloid-PET burden and in APOEÉ4 carriers.Conclusions:
Our study highlights that plasma total tau is a marker of amyloid deposition as early as in middle-age.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas tau
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Tomografia por Emissão de Pósitrons
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article