Polystyrene nanoplastics exposure causes erectile dysfunction in rats.
Ecotoxicol Environ Saf
; 280: 116551, 2024 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-38875818
ABSTRACT
Polystyrene nanoplastics (PS-NPs), emerging and increasingly pervasive environmental contaminants, have the potential to cause persistent harm to organisms. Although previous reports have documented local accumulation and adverse effects in a variety of major organs after PS-NPs exposure, the impact of PS-NPs exposure on erectile function remains unexplored. Herein, we established a rat model of oral exposure to 100â¯nm PS-NPs for 28 days. To determine the best dose range of PS-NPs, we designed both low-dose and high-dose PS-NPs groups, which correspond to the minimum and maximum human intake doses, respectively. The findings indicated that PS-NPs could accumulate within the corpus cavernosum and high dose but not low dose of PS-NPs triggered erectile dysfunction. Moreover, the toxicological effects of PS-NPs on erectile function include fibrosis in the corpus cavernous, endothelial dysfunction, reduction in testosterone levels, elevated oxidative stress and apoptosis. Overall, this study revealed that PS-NPs exposure can cause erectile dysfunction via multiple ways, which provided new insights into the toxicity of PS-NPs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pênis
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Poliestirenos
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Ratos Sprague-Dawley
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Estresse Oxidativo
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Disfunção Erétil
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article