Lack of selection of antimalarial drug resistance markers after intermittent preventive treatment of schoolchildren (IPTsc) against malaria in northeastern Tanzania.
Int J Infect Dis
; 146: 107102, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38876161
ABSTRACT
OBJECTIVE:
Intermittent Preventive Treatment of schoolchildren (IPTsc) is recommended by WHO as a strategy to protect against malaria; to explore whether IPTsc with dihydroartemisinin-piperaquine (DP) or artesunate-amodiaquine (ASAQ) cause a selection of molecular markers in Plasmodium falciparum genes associated with resistance in children in seven schools in Tanga region, Tanzania.METHODS:
SNPs in P. falciparum genes Pfmdr1, Pfexo, Pfkelch13, and Pfcrt and copy number variations in Pfplasmepsin-2 and Pfmdr1 were assessed in samples collected at 12 months (visit 4, n=74) and 20 months (visit 6, n=364) after initiation of IPTsc and compared with the baseline prevalence (n=379).RESULTS:
The prevalence of Pfmdr1 N86 and Pfexo 415G was >99% and 0%, respectively without any temporal differences observed. The prevalence of Pfmdr1 184F changed significantly from baseline (52.2%) to visit 6 (64.6%) (χ2=6.11, P=0.013), but no differences were observed between the treatment arms (χ2=0.05, P=0.98). Finally, only minor differences in the amplification of Pfmdr1 were observed; from 10.2% at baseline to 16.7% at visit 6 (χ2=0.98, P=0.32).CONCLUSIONS:
The IPTsc strategy does not seem to pose a risk for the selection of markers associated with DP or ASAQ resistance. Continuously and timely surveillance of markers of antimalarial drug resistance is recommended.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
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Resistência a Medicamentos
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Malária Falciparum
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Artemisininas
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Combinação de Medicamentos
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Amodiaquina
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Antimaláricos
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article