Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus.
Elife
; 122024 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-38884573
ABSTRACT
Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown. Here, we show that GABAergic neurons in the preoptic area of the hypothalamus projecting to the tuberomammillary nucleus (POAGAD2âTMN neurons) are crucial for the homeostatic regulation of REMs in mice. POAGAD2âTMN neurons are most active during REMs, and inhibiting them specifically decreases REMs. REMs restriction leads to an increased number and amplitude of calcium transients in POAGAD2âTMN neurons, reflecting the accumulation of REMs pressure. Inhibiting POAGAD2âTMN neurons during REMs restriction blocked the subsequent rebound of REMs. Our findings reveal a hypothalamic circuit whose activity mirrors the buildup of homeostatic REMs pressure during restriction and that is required for the ensuing rebound in REMs.
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Base de dados:
MEDLINE
Assunto principal:
Área Pré-Óptica
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Sono REM
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Neurônios GABAérgicos
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Homeostase
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article