Association of Metabolic Syndrome With Neuroimaging and Cognitive Outcomes in the UK Biobank.
Diabetes Care
; 47(8): 1415-1423, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38894691
ABSTRACT
OBJECTIVE:
Metabolic syndrome (MetS) has been linked to dementia. In this study, we examined the association of MetS with neuroimaging and cognition in dementia-free adults, offering insight into the impact of MetS on brain health prior to dementia onset. RESEARCH DESIGN ANDMETHODS:
We included 37,395 dementia-free adults from the UK Biobank database. MetS was defined as having at least three of the following components larger waist circumference; elevated levels of triglycerides, blood pressure, HbA1c; or reduced HDL cholesterol levels. Multivariable-adjusted linear regression was used to assess associations of MetS with structural neuroimaging and cognitive domains.RESULTS:
MetS was associated with lower total brain (standardized ß -0.06; 95% CI -0.08, -0.04), gray matter (ß -0.10; 95% CI -0.12, -0.08) and hippocampal (for left side, ß -0.03, 95% CI -0.05, -0.01; for right side, ß -0.04, 95% CI -0.07, -0.02) volumes, and greater white matter hyperintensity (WMH) volume (ß 0.08; 95% CI 0.06, 0.11). Study participants with MetS performed poorer on cognitive tests of working memory (ß -0.10; 95% CI -0.13, -0.07), verbal declarative memory (ß -0.08; 95% CI -0.11, -0.05), processing speed (ß -0.06; 95% CI -0.09, -0.04), verbal and numerical reasoning (ß -0.07; 95% CI -0.09, -0.04), nonverbal reasoning (ß -0.03; 95% CI -0.05, -0.01), and on tests of executive function, where higher scores indicated poorer performance (ß 0.05; 95% CI 0.03, 0.08). More MetS components were also associated with less brain volume, greater WMH, and poorer cognition across all domains.CONCLUSIONS:
MetS was associated poorer brain health in dementia-free adults, characterized by less brain volume, greater vascular pathology, and poorer cognition. Further research is necessary to understand whether reversal or improvement of MetS can improve brain health.
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Base de dados:
MEDLINE
Assunto principal:
Cognição
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Bancos de Espécimes Biológicos
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Síndrome Metabólica
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Neuroimagem
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article