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Crystal structure of MAGEA4 MHD-RAD18 R6BD reveals a flipped binding mode compared to AlphaFold2 prediction.
Forker, Karly; Fleming, Matthew C; Pearce, Kenneth H; Vaziri, Cyrus; Bowers, Albert A; Zhou, Pei.
Afiliação
  • Forker K; Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
  • Fleming MC; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Pearce KH; Nimble Therapeutics, 603 Science Dr, Madison, WI, 53711, USA.
  • Vaziri C; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Bowers AA; Curriculum in Genetics and Molecular Biology, Department of Pathology and Laboratory Medicine, and Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Zhou P; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
EMBO J ; 43(14): 2835-2839, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38907034
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ligação Proteica Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ligação Proteica Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article