HLA Typing and Mutation Calling from Normal and Tumor Whole Genome Sequencing Data with ALPHLARD-NT.
Methods Mol Biol
; 2809: 101-113, 2024.
Article
em En
| MEDLINE
| ID: mdl-38907893
ABSTRACT
HLA somatic mutations can alter the expression and function of HLA molecules, which in turn affect the ability of the immune system to recognize and respond to cancer cells. Therefore, it is crucial to accurately identify HLA somatic mutations to enhance our understanding of the interaction between cancer and the immune system and improve cancer treatment strategies. ALPHLARD-NT is a reliable tool that can accurately identify HLA somatic mutations as well as HLA genotypes from whole genome sequencing data of paired normal and tumor samples. Here, we provide a comprehensive guide on how to use ALPHLARD-NT and interpret the results.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Teste de Histocompatibilidade
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Sequenciamento Completo do Genoma
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Antígenos HLA
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Mutação
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article