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High prevalence of albuminuria among adult males living with HIV in Botswana.
Mosepele, Mosepele; Ponatshego, Ponego; Molebatsi, Kesaobaka; Williams, Christopher; Mokgatlhe, Lucky; Lockman, Shahin; Youssouf, Nabila; Gross, Robert; Jarvis, Joseph; Wang, Duolao; Jaffar, Shabbar.
Afiliação
  • Mosepele M; Botswana Harvard Health Partnership, Gaborone, Botswana. mosepelemosepele@gmail.com.
  • Ponatshego P; Faculty of Medicine, University of Botswana, Gaborone, Botswana. mosepelemosepele@gmail.com.
  • Molebatsi K; Harvard T.H. Chan School of Public Health, Harvard University, Boston, USA. mosepelemosepele@gmail.com.
  • Williams C; Botswana Harvard Health Partnership, Gaborone, Botswana.
  • Mokgatlhe L; Department of Statistics, University of Botswana, Gaborone, Botswana.
  • Lockman S; Botswana Harvard Health Partnership, Gaborone, Botswana.
  • Youssouf N; Department of Statistics, University of Botswana, Gaborone, Botswana.
  • Gross R; Botswana Harvard Health Partnership, Gaborone, Botswana.
  • Jarvis J; Harvard T.H. Chan School of Public Health, Harvard University, Boston, USA.
  • Wang D; Botswana Harvard Health Partnership, Gaborone, Botswana.
  • Jaffar S; London School of Hygiene and Tropical Medicine, London, UK.
Sci Rep ; 14(1): 14432, 2024 06 23.
Article em En | MEDLINE | ID: mdl-38910157
ABSTRACT
Chronic HIV disease is associated with a fivefold increase in albuminuria outside of sub-Saharan Africa. However, very little is known about albuminuria risk among people living with HIV (PLWH) in sub-Saharan Africa. Therefore, we conducted a cross-sectional observational HIV clinic-based study of albuminuria among 1533 adults aged 21 years or older between January 2020 and January 2021 in Gaborone, Botswana. Clinical albuminuria was defined using a sex-based albumin‒creatinine ratio (ACR) of 25-355 mg/g for females and 17-250 mg/g for males. The study population mean age was 48.5 (SD 10.3) years, and 764/1533 (49.7%) were female. The overall prevalence of albuminuria was 20.7% (95% CI 18.7%, 22.8%). A higher proportion of males were more likely to be categorized as having albuminuria than females, 25% (95% CI 22.0, 28.2) versus 16.4% (95% CI 13.8,19.2), P value < 0.001. In the final multivariate models, predictors of albuminuria differed by sex group. Larger longitudinal studies are required to evaluate the impact of albuminuria among PLWH with particular emphasis on the effect of sex on the risk of albuminuria.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Albuminúria Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Albuminúria Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article