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Intravenous Bolus of Dexmedetomidine for Treatment of Severe Shivering After Caesarean Delivery Under Combined Spinal-Epidural Anaesthesia: A Randomized Dose-Response Study.
Yang, Meijuan; Li, ShuXi; Drzymalski, Dan; Chen, Xinzhong.
Afiliação
  • Yang M; Department of Anaesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Li S; Department of Anaesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Drzymalski D; Department of Anaesthesiology and Perioperative Medicine, Tufts Medical Centre, Boston, MA, USA.
  • Chen X; Department of Anaesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Drug Des Devel Ther ; 18: 2393-2402, 2024.
Article em En | MEDLINE | ID: mdl-38911029
ABSTRACT

Purpose:

Shivering occurs frequently after caesarean delivery. The present study aimed to investigate the ED50 and ED95 of an intravenous (i.v.) bolus of dexmedetomidine for treating severe shivering after caesarean delivery under combined spinal-epidural anaesthesia. Patients and

methods:

Seventy-five parturients with severe shivering after caesarean delivery were randomized into one of the five groups to receive an i.v. bolus of 0.2 (Group D1), 0.25 (Group D2), 0.3 (Group D3), 0.35 (Group D4) or 0.4 (Group D5) µg/kg of dexmedetomidine. Effectiveness of shivering treatment was defined as a standardized shivering score decreasing to ≤1 within 10 min of dexmedetomidine injection. The ED50 and ED95 were determined by probit regression. Adverse effects were also compared among the groups.

Results:

The ED50 and ED95 of i.v. dexmedetomidine to treat severe shivering were 0.23 (95% CI, 0.16-0.26) µg/kg and 0.39 (95% CI, 0.34-0.52) µg/kg, respectively. No difference in the incidence of adverse effects was found between groups.

Conclusion:

An i.v. bolus of 0.39 µg/kg of dexmedetomidine will treat 95% of parturients experiencing severe shivering after caesarean delivery.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estremecimento / Cesárea / Dexmedetomidina / Relação Dose-Resposta a Droga / Anestesia Epidural / Raquianestesia Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estremecimento / Cesárea / Dexmedetomidina / Relação Dose-Resposta a Droga / Anestesia Epidural / Raquianestesia Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article