Cerebrospinal fluid distribution and pharmacokinetics of ponatinib in Ph1+ acute lymphoblastic leukemia.
Blood
; 144(10): 1127-1130, 2024 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-38917352
ABSTRACT
ABSTRACT Tyrosine kinase inhibitors efficacy in central nervous system (CNS) disease remains uncertain. Ponatinib was studied for CNS distribution in 16 patients with Philadelphia-positive acute lymphoblastic leukemia. Cerebrospinal fluid concentrations fell below the 40 nM threshold, suggesting suboptimal CNS exposure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Inibidores de Proteínas Quinases
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Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Imidazóis
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article