Milestones in tumor vascularization and its therapeutic targeting.
Nat Cancer
; 5(6): 827-843, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38918437
ABSTRACT
Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and experimental demonstrations that angiogenesis is instrumental for tumor growth and was, therefore, a promising therapeutic target. The biological knowledge and therapeutic insights forthcoming have been remarkable, punctuated by new concepts, many of which were not foreseen in the early decades. This article presents a perspective on tumor vascularization and its therapeutic targeting but does not portray a historical timeline. Rather, we highlight eight conceptual milestones, integrating initial discoveries and recent progress and posing open questions for the future.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias
/
Neovascularização Patológica
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article