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Discovery of Sesquiterpene Lactones with Cytotoxicity from the Herb of Youngia japonica.
Ye, Xian-Sheng; Lin, Kuan; Tao, Xiao-Qing; Shang, Jin-Ting; Gui, Yu-Ran; Zhu, Shu-Xiu; Zhou, Le; Xia, Yi-Yuan; Liu, Wei; Sun, Bin-Lian; Chen, Hai-Feng; Shu, Xi-Ji.
Afiliação
  • Ye XS; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Lin K; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Tao XQ; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Shang JT; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Gui YR; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Zhu SX; Department of Traditional Chinese Medicine, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Zhou L; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Guangzhou, 510000, China.
  • Xia YY; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Liu W; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Sun BL; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Chen HF; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
  • Shu XJ; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
Chem Biodivers ; 21(9): e202401063, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38924351
ABSTRACT
In the process of searching for anti-breast cancer agents, five sesquiterpene lactones (1-5), including two previously undescribed ones, yjaponica B-C (1-2), were isolated from the herb of Youngia japonica. Their structures were elucidated by spectroscopic data analyses and Marfey's method. Cytotoxic activities of all compounds against A549, U87, and 4T1 cell lines were tested using the CCK8 assay. The result showed that compound 3 possessed the highest cytotoxic activity against 4T1 cells with an IC50 value of 10.60 µM. Furthermore, compound 3 distinctly induced apoptosis, inhibited immigration, and blocked the cell cycle of 4T1 cells. In addition, compound 3 induced the production of reactive oxygen species. Further anticancer mechanism studies showed that compound 3 significantly upregulated expression of the cleaved caspase 3 and PARP, whereas it downregulated the expression of Bcl-2, cyclin D1, cyclin A2, CDK4, and CDK2. Taken together, our results demonstrate that compound 3 has a high potential of being used as a leading compound for the discovery of new anti-breast cancer agent.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Ensaios de Seleção de Medicamentos Antitumorais / Apoptose / Proliferação de Células / Lactonas / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Ensaios de Seleção de Medicamentos Antitumorais / Apoptose / Proliferação de Células / Lactonas / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article