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Surgical and radiosurgical treatment of hypothalamic hamartoma: The Italian experience between 2011 and 2021.
Rizzi, Michele; Consales, Alessandro; Tramacere, Irene; De Benedictis, Alessandro; Bua, Antonella; Specchio, Nicola; De Palma, Luca; Cognolato, Erica; Nobili, Lino; Tortora, Domenico; Barba, Carmen; Pommella, Marianna; Giordano, Flavio; Pastori, Chiara; Marchetti, Marcello; Garbelli, Rita; Zucchelli, Mino; Martinoni, Matteo; Ferri, Lorenzo; Martucci, Matia; Tamburrini, Gianpiero; Bianchi, Federico; Passamonti, Claudia; Di Gennaro, Giancarlo; Villani, Flavio; Tassi, Laura; Marras, Carlo.
Afiliação
  • Rizzi M; Functional Neurosurgery Unit, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  • Consales A; Neurosurgery Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
  • Tramacere I; Department of Research and Clinical Development, Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  • De Benedictis A; Neurosurgery Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Bua A; Neurosurgery Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Specchio N; Clinical and Experimental Neurology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • De Palma L; Clinical and Experimental Neurology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Cognolato E; Child Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
  • Nobili L; Child Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
  • Tortora D; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
  • Barba C; Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
  • Pommella M; Neuroscience Department, Meyer Children's Hospital IRCCs, Florence, Italy.
  • Giordano F; Department of Neurosciences, University of Florence, Florence, Italy.
  • Pastori C; Neuroscience Department, Meyer Children's Hospital IRCCs, Florence, Italy.
  • Marchetti M; Department of Neurosciences, University of Florence, Florence, Italy.
  • Garbelli R; Department of Neurosciences, University of Florence, Florence, Italy.
  • Zucchelli M; Neurosurgery Unit, Meyer Children's Hospital IRCCs, Florence, Italy.
  • Martinoni M; Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  • Ferri L; Unit of Radiotherapy, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  • Martucci M; Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  • Tamburrini G; IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Bianchi F; IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Passamonti C; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Di Gennaro G; Diagnostic Neuroradiology Unit, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.
  • Villani F; Università Cattolica del Sacro Cuore, Rome, Italy.
  • Tassi L; Università Cattolica del Sacro Cuore, Rome, Italy.
  • Marras C; Pediatric Neurosurgery, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.
Epilepsia Open ; 9(4): 1493-1501, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38926936
ABSTRACT

OBJECTIVE:

To investigate the Italian experience on the surgical and radiosurgical treatment of drug-resistant epilepsy due to hypothalamic hamartoma (HH) in the period 2011-2021 in six Italian epilepsy surgery centers, and to compare safety and efficacy profiles of the different techniques.

METHODS:

We collected pseudo-anonymized patient's data with at least 12 months of follow-up. Surgical outcome was defined according to Engel classification of seizure outcome. Univariate analysis was performed to assess the risk of post-operative seizures, categorized in dichotomous variable as favorable and unfavorable; explanatory variables were considered. Mann-Whitney or Chi-squared test were used to assess the presence of an association between variables (p < 0.05).

RESULTS:

Full presurgical and postoperative data about 42 patients from 6 epilepsy surgery centers were gathered. Engel class I was reached in the 65.8% and 66.6% of patients with gelastic and non-gelastic seizures, respectively. Other than daily non-gelastic seizures were associated with seizure freedom (p = 0.01), and the radiological type presented a trend toward significance (p = 0.12).

SIGNIFICANCE:

Endoscopic disconnection and laser interstitial thermal therapy are effective in the treatment of HH-related epilepsy, with a tolerable safety profile. Both gelastic and non-gelastic seizures can be treated, also in patients with a long history of seizures. PLAIN LANGUAGE

SUMMARY:

This study collected data about 42 patients with HH-related epilepsies. Endoscopic disconnection and laser therapy are both effective and safe in the treatment of hypothalamic hamartoma-related epilepsies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radiocirurgia / Hamartoma / Doenças Hipotalâmicas Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radiocirurgia / Hamartoma / Doenças Hipotalâmicas Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article