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Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children.
Li, Yijie; Baumert, Brittney O; Stratakis, Nikos; Goodrich, Jesse A; Wu, Haotian; Liu, Shelley H; Wang, Hongxu; Beglarian, Emily; Bartell, Scott M; Eckel, Sandrah Proctor; Walker, Douglas; Valvi, Damaskini; La Merrill, Michele Andrea; Inge, Thomas H; Jenkins, Todd; Ryder, Justin R; Sisley, Stephanie; Kohli, Rohit; Xanthakos, Stavra A; Vafeiadi, Marina; Margetaki, Aikaterini; Roumeliotaki, Theano; Aung, Max; McConnell, Rob; Baccarelli, Andrea; Conti, David; Chatzi, Lida.
Afiliação
  • Li Y; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Baumert BO; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Stratakis N; Barcelona Institute of Global Health, Barcelona, Spain.
  • Goodrich JA; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Wu H; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
  • Liu SH; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Wang H; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Beglarian E; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Bartell SM; Department of Environmental and Occupational Health and Department of Epidemiology and Biostatistics, University of California, Irvine, CA, USA.
  • Eckel SP; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Walker D; Gangarosa Department of Environmental Health, Rollins School of Public Health, 1518 Clifton Road, NE, Atlanta, GA, USA.
  • Valvi D; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • La Merrill MA; Department of Environmental Toxicology, University of California, Davis, CA, USA.
  • Inge TH; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
  • Jenkins T; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.
  • Ryder JR; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
  • Sisley S; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • Kohli R; Division of Gastroenterology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
  • Xanthakos SA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Vafeiadi M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
  • Margetaki A; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
  • Roumeliotaki T; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Department of Social Medicine, School of Medicine, University of Crete, Greece.
  • Aung M; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • McConnell R; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Baccarelli A; Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Conti D; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Chatzi L; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: chatzi@usc.edu.
Environ Res ; 259: 119496, 2024 Oct 15.
Article em En | MEDLINE | ID: mdl-38936497
ABSTRACT

BACKGROUND:

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However, little is known about the associations between PFAS exposures and miRNA alterations in humans.

OBJECTIVE:

To investigate associations between PFAS concentrations and miRNA levels in children.

METHODS:

Data from two distinct cohorts were utilized 176 participants (average age 17.1 years; 75.6% female) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort in the United States, and 64 participants (average age 6.5 years, 39.1% female) from the Rhea study, a mother-child cohort in Greece. PFAS concentrations and miRNA levels were assessed in plasma samples from both studies. Associations between individual PFAS and plasma miRNA levels were examined after adjusting for covariates. Additionally, the cumulative effects of PFAS mixtures were evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed to identify potential disease functions of PFAS-associated miRNAs.

RESULTS:

Plasma PFAS concentrations were associated with alterations in 475 miRNAs in the Teen-LABs study and 5 miRNAs in the Rhea study (FDR p < 0.1). Specifically, plasma PFAS concentrations were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p in both cohorts. Pathway analysis indicated that PFAS-related miRNAs were linked to numerous chronic disease pathways, including cardiovascular diseases, inflammatory conditions, and carcinogenesis.

CONCLUSION:

Through miRNA screenings in two independent cohorts, this study identified both known and novel miRNAs associated with PFAS exposure in children. Pathway analysis revealed the involvement of these miRNAs in several cancer and inflammation-related pathways. Further studies are warranted to enhance our understanding of the relationships between PFAS exposure and disease risks, with miRNA emerging as potential biomarkers and/or mediators in these complex pathways.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Exposição Ambiental / Poluentes Ambientais / Fluorocarbonos Limite: Adolescent / Child / Female / Humans / Male País como assunto: America do norte / Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Exposição Ambiental / Poluentes Ambientais / Fluorocarbonos Limite: Adolescent / Child / Female / Humans / Male País como assunto: America do norte / Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article