Clinical Course of TGA After Arterial Switch Operation in the Current Era.
JACC Adv
; 3(2): 100772, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38939383
ABSTRACT
Background:
The number of patients with an arterial switch operation (ASO) for transposition of the great arteries (TGA) is steadily growing; limited information is available regarding the clinical course in the current era.Objectives:
The purpose was to describe clinical outcome late after ASO in a national cohort, including survival, rates of (re-)interventions, and clinical events.Methods:
A total of 1,061 TGA-ASO patients (median age 10.7 years [IQR 2.0-18.2 years]) from a nationwide prospective registry with a median follow-up of 8.0 years (IQR 5.4-8.8 years) were included. Using an analysis with age as the primary time scale, cumulative incidence of survival, (re)interventions, and clinical events were determined.Results:
At the age of 35 years, late survival was 93% (95% CI 88%-98%). The cumulative re-intervention rate at the right ventricular outflow tract and pulmonary branches was 36% (95% CI 31%-41%). Other cumulative re-intervention rates at 35 years were on the left ventricular outflow tract (neo-aortic root and valve) 16% (95% CI 10%-22%), aortic arch 9% (95% CI 5%-13%), and coronary arteries 3% (95% CI 1%-6%). Furthermore, 11% (95% CI 6%-16%) of the patients required electrophysiological interventions. Clinical events, including heart failure, endocarditis, and myocardial infarction occurred in 8% (95% CI 5%-11%). Independent risk factors for any (re-)intervention were TGA morphological subtype (Taussig-Bing double outlet right ventricle [HR 4.9, 95% CI 2.9-8.1]) and previous pulmonary artery banding (HR 1.6, 95% CI 1.0-2.2).Conclusions:
TGA-ASO patients have an excellent survival. However, their clinical course is characterized by an ongoing need for (re-)interventions, especially on the right ventricular outflow tract and the left ventricular outflow tract indicating a strict lifelong surveillance, also in adulthood.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article