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Development of fexofenadine self-microemulsifying delivery systems: an efficient way to improve intestinal permeability.
Islambulchilar, Ziba; Barfar, Ashkan; Mirzaeei, Shahla.
Afiliação
  • Islambulchilar Z; Department of Pharmaceutics, Faculty of pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Barfar A; Department of Pharmaceutics, Faculty of pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mirzaeei S; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ther Deliv ; 15(8): 593-604, 2024.
Article em En | MEDLINE | ID: mdl-38941109
ABSTRACT

Aim:

The present study aimed to prepare and evaluate fexofenadine self-microemulsifying drug-delivery systems (SMEDDS) formulation and to determine and compare its intestinal permeability using in situ single-pass intestinal perfusion (SPIP) technique.

Methods:

Fexofenadine-loaded SMEDDS were prepared and optimized. Droplet size, polydispersity index, zeta potential, drug release and intestinal permeability were evaluated.

Results:

Optimized formulation consisted of 15% oil, 80% surfactant and 5% cosolvent. Droplet size and drug loading of optimized formulation was 13.77 nm and 60 mg/g and it has released 90% of its drug content. Intestinal permeability of fexofenadine was threefold enhanced in SMEDDS compared with free fexofenadine.

Conclusion:

The results of our study revealed that SMEDDS could be a promising tool for oral delivery of fexofenadine with enhanced dissolution rate and intestinal permeability.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Permeabilidade / Terfenadina / Sistemas de Liberação de Medicamentos / Emulsões / Absorção Intestinal Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Permeabilidade / Terfenadina / Sistemas de Liberação de Medicamentos / Emulsões / Absorção Intestinal Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article