Neurofeedback-enabled beta power control with a fully implanted DBS system in patients with Parkinson's disease.

Rohr-Fukuma, Manabu; Stieglitz, Lennart H; Bujan, Bartosz; Jedrysiak, Piotr; Oertel, Markus F; Salzmann, Lena; Baumann, Christian R; Imbach, Lukas L; Gassert, Roger; Bichsel, Oliver

Rohr-Fukuma, Manabu; Stieglitz, Lennart H; Bujan, Bartosz; Jedrysiak, Piotr; Oertel, Markus F; Salzmann, Lena; Baumann, Christian R; Imbach, Lukas L; Gassert, Roger; Bichsel, Oliver.

Afiliação

Rohr-Fukuma M; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Switzerland; Clinical Neuroscience Centre, University Hospital Zurich, University of Zurich, Switzerland.
Stieglitz LH; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Switzerland; Clinical Neuroscience Centre, University Hospital Zurich, University of Zurich, Switzerland.
Bujan B; Neurorehabilitation, Klinik Lengg, Switzerland.
Jedrysiak P; Neurorehabilitation, Klinik Lengg, Switzerland.
Oertel MF; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Switzerland; Clinical Neuroscience Centre, University Hospital Zurich, University of Zurich, Switzerland.
Salzmann L; Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland.
Baumann CR; Clinical Neuroscience Centre, University Hospital Zurich, University of Zurich, Switzerland; Department of Neurology, University Hospital Zurich, University of Zurich, Switzerland.
Imbach LL; Swiss Epilepsy Center, Klinik Lengg, Switzerland.
Gassert R; Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland.
Bichsel O; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Switzerland; Clinical Neuroscience Centre, University Hospital Zurich, University of Zurich, Switzerland; Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, Switzerland. Electr

Clin Neurophysiol ; 165: 1-15, 2024 Jun 13.

Article em En | MEDLINE | ID: mdl-38941959

ABSTRACT

ABSTRACT

OBJECTIVE:

Parkinsonian motor symptoms are linked to pathologically increased beta oscillations in the basal ganglia. Studies with externalised deep brain stimulation electrodes showed that Parkinson patients were able to rapidly gain control over these pathological basal ganglia signals through neurofeedback. Studies with fully implanted deep brain stimulation systems duplicating these promising results are required to grant transferability to daily application.

METHODS:

In this study, seven patients with idiopathic Parkinson's disease and one with familial Parkinson's disease were included. In a postoperative setting, beta oscillations from the subthalamic nucleus were recorded with a fully implanted deep brain stimulation system and converted to a real-time visual feedback signal. Participants were instructed to perform bidirectional neurofeedback tasks with the aim to modulate these oscillations.

RESULTS:

While receiving regular medication and deep brain stimulation, participants were able to significantly improve their neurofeedback ability and achieved a significant decrease of subthalamic beta power (median reduction of 31% in the final neurofeedback block).

CONCLUSION:

We could demonstrate that a fully implanted deep brain stimulation system can provide visual neurofeedback enabling patients with Parkinson's disease to rapidly control pathological subthalamic beta oscillations.