Endolysosomal trapping of therapeutics and endosomal escape strategies.
Drug Discov Today
; 29(8): 104070, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38942071
ABSTRACT
Internalizing therapeutic molecules or genes into cells and safely delivering them to the target tissue where they can perform the intended tasks is one of the key characteristics of the smart gene/drug delivery vector. Despite much research in this field, endosomal escape continues to be a significant obstacle to the development of effective gene/drug delivery systems. In this review, we discuss in depth the several types of endocytic pathways involved in the endolysosomal trapping of therapeutic agents. In addition, we describe numerous mechanisms involved in nanoparticle endosomal escape. Furthermore, many other techniques are employed to increase endosomal escape to minimize entrapment of therapeutic compounds within endolysosomes, which have been reviewed at length in this study.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Endossomos
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Sistemas de Liberação de Medicamentos
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Lisossomos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article