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Impaired cognition in narcolepsy: clinical and neurobiological perspectives.
Cano, Christopher A; Harel, Brian T; Scammell, Thomas E.
Afiliação
  • Cano CA; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Harel BT; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
  • Scammell TE; Neuroscience Therapeutic Area Unit, Takeda Development Center Americas Inc., Cambridge, MA, USA.
Sleep ; 47(9)2024 Sep 09.
Article em En | MEDLINE | ID: mdl-38943485
ABSTRACT
In addition to well-known symptoms such as sleepiness and cataplexy, many people with narcolepsy have impaired cognition, reporting inattention, poor memory, and other concerns. Unfortunately, research on cognition in narcolepsy has been limited. Strong evidence demonstrates difficulties with sustained attention, but evidence for executive dysfunction and impaired memory is mixed. Animal research provides some insights into how loss of the orexin neurons in narcolepsy type 1 may give rise to impaired cognition via dysfunction of the prefrontal cortex, and cholinergic and monoaminergic systems. This paper reviews some of these clinical and preclinical findings, provides a neurobiological framework to understand these deficits, and highlights some of the many key unanswered questions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Narcolepsia Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Narcolepsia Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article